Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: results of two placebo-controlled trials

For most patients, the recommended dose of FLEXERIL is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of FLEXERIL for periods longer than two or three weeks is not recommended. Sometimes people will even have a heart attack or develop seizures. In order to quit safely, you need to opt for professional Flexeril rehab.

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Physical examination data were listed, and any new physical findings were summarized. Selected ECG variables were summarized at baseline and at the end of treatment, and treatments were compared using a 2-sample t test for actual value and change from baseline. The proportions of patients with a normal ECG were compared at baseline and end of treatment by Fisher’s exact test.

Patient Handout

Your dose will depend on the severity of your pain and the formulation of cyclobenzaprine you’re using. Don’t take this medicine for longer than three weeks without talking to your doctor. Call your doctor if your symptoms do not improve after 3 weeks, or if they get worse.

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For example, the peak concentration for the extended-release pills is around seven hours. Overdose symptoms may include severe drowsiness, vomiting, fast heartbeats, tremors, agitation, or hallucinations. Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. It’s not considered a dangerous method of getting rid of specific muscular pain. It is given to patients who are more likely to abuse opiate pain killers and is considered less risky for abuse and addiction.

What Is Flexeril Discontinuation Syndrome?

Another potential side effect of Flexeril abuse is cyclobenzaprine overdose, especially if taken in conjunction with other substances such as other CNS depressants like alcohol. Flexeril causes the body to become relaxed and abusing the substance in high doses can lead to cardiac arrest, low blood pressure, heart attack, and seizures. Taking Flexeril in the recommended dosage and for the right length of time should pose little to no risk of dependence or addiction forming. Abusing the drug in higher doses or combining it with other central nervous system depressants like benzodiazepines increases the risk of addiction as well as the potential for overdose.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

• This is especially true if someone has been engaging in polydrug use with cyclobenzaprine and other substances.
• The dose of this medicine will be different for different patients.
• It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
• Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction.

There are some restrictions as to who can take this drug. The FDA recommends cautious use of cyclobenzaprine in patients with a history of urinary retention and glaucoma or other eye problems. As a result, the FDA cautions use during pregnancy only if clearly needed.

Do not take this drug again if you’ve ever had an allergic reaction to it. If you’re taking Flexeril non-medically for a high—with or without other drugs—treatment for substance abuse can you take hydrocodone/acetaminophen with flexeril can prevent you from suffering a dangerous overdose. Analysis of the data from controlled studies shows that FLEXERIL produces clinical improvement whether or not sedation occurs.

During pregnancy, this medication should be used only when clearly needed. Animal studies don’t always predict the way humans would respond. Therefore, this drug should only be used in pregnancy if clearly needed. Many insurance companies require prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription. If you have liver problems, your doctor may do a blood test to monitor how well your liver is working while you take this drug.

For nursing mothers, it is unknown if cyclobenzaprine is excreted in human milk. However, because it is closely related to tricyclic antidepressants, which are excreted in human milk, the FDA cautions against breastfeeding if using cyclobenzaprine. Cyclobenzaprine is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries.